OSTEOARTHRITIS (OA) is a most common form of arthritis. Sometimes it is called degenerative joint disease or “wear and tear” arthritis. Occurs most frequently in the hands, hips, and knees
Pathophysiology
- Hyaline cartilage provides a smooth, gliding surface for joint motion and acts as a cushion between the bones
- In OA, the cartilage breaks down, causing pain, swelling and problems moving the joint
- OA worsens over time, bones may break down and develop growths called spurs. Bits of bone or cartilage may flake off and float around in the joint
- In the body, an inflammatory process occurs and cytokines (proteins) and enzymes develop that further damage the cartilage. In the final stages of OA, the cartilage wears away and bone rubs against bone leading to joint damage and more pain
Causes
Damage or breakdown of joint cartilage between bones.